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TargetAurora kinase A
LigandBDBM31866
Substrate/CompetitorHistone H3 (aa 1-18)
Meas. Tech.Enzyme Inhibition Assay
IC50 67±n/a nM
Citation Aliagas-Martin, IBurdick, DCorson, LDotson, JDrummond, JFields, CHuang, OWHunsaker, TKleinheinz, TKrueger, ELiang, JMoffat, JPhillips, GPulk, RRawson, TEUltsch, MWalker, LWiesmann, CZhang, BZhu, BYCochran, AG A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. J Med Chem52:3300-7 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Aurora kinase A
Name:Aurora kinase A
Synonyms:AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1
Type:Serine/threonine-protein kinase
Mol. Mass.:45830.98
Organism:Homo sapiens (Human)
Description:O14965
Residue:403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
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BDBM31866
Histone H3 (aa 1-18)
Name:Histone H3 (aa 1-18)
Synonyms:GST fusion of N-terminus of Histone H3 (aa 1-18) | H31_HUMAN | H3C1 | H3FA | H3FB | H3FC HIST1H3C | H3FD | H3FF | H3FH | H3FI | H3FJ | H3FK | H3FL | HIST1H3A | HIST1H3B | HIST1H3D | HIST1H3E | HIST1H3F | HIST1H3G | HIST1H3H | HIST1H3I | HIST1H3J | Histone H3
Type:Peptide
Mol. Mass.:1951.30
Organism:Homo sapiens (Human)
Description:P68431 (aa 1-18)
Residue:18
Sequence:
MARTKQTARKSTGGKAPR
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