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TargetDimer of Gag-Pol polyprotein [514-612]
LigandBDBM517
Substrate/CompetitorHIV-1 Protease substrate
Meas. Tech.Protease Inhibition Assay
pH5.5±n/a
Temperature303.15±n/a K
Ki 3.316±0.300 nM
Commentskcat/Km=0.42 /sec/mM
Citation Vacca, JP; Dorsey, BD; Schleif, WA; Levin, RB; McDaniel, SL; Darke, PL; Zugay, J; Quintero, JC; Blahy, OM; Roth, E L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor. Proc Natl Acad Sci U S A91:4096-100 (1994) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Dimer of Gag-Pol polyprotein [514-612]
Name:Dimer of Gag-Pol polyprotein [514-612]
Synonyms:HIV-2 Protease
Type:Protein Complex
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Gag-Pol polyprotein [514-612]
Synonyms:HIV-2 Protease chain A | HIV-2 Protease chain B | POL_HV2RO | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10718.25
Organism:Human immunodeficiency virus type 2
Description:P04584[514-612]
Residue:99
Sequence:
PQFSLWKRPVVTAYIEGQPVEVLLDTGADDSIVAGIELGNNYSPKIVGGIGGFINTKEYK
NVEIEVLNKKVRATIMTGDTPINIFGRNILTALGMSLNL
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  Blast E-value cutoff:
Component 2
Name:Gag-Pol polyprotein [514-612]
Synonyms:HIV-2 Protease chain A | HIV-2 Protease chain B | POL_HV2RO | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10718.25
Organism:Human immunodeficiency virus type 2
Description:P04584[514-612]
Residue:99
Sequence:
PQFSLWKRPVVTAYIEGQPVEVLLDTGADDSIVAGIELGNNYSPKIVGGIGGFINTKEYK
NVEIEVLNKKVRATIMTGDTPINIFGRNILTALGMSLNL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM517
HIV-1 Protease substrate
Name:HIV-1 Protease substrate
Synonyms:HIV Protease Peptide Substrate
Type:Peptide
Mol. Mass.:4082.51
Organism:n/a
Description:n/a
Residue:38
Sequence:
Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val