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TargetProcathepsin L [114-333,T223A]
LigandBDBM31978
Substrate/CompetitorBDBM22047
Meas. Tech.Cathepsin Inhibition Assay
pH7±n/a
Temperature310.15±n/a K
IC50 79±n/a nM
Citation Asaad, NBethel, PACoulson, MDDawson, JEFord, SJGerhardt, SGrist, MHamlin, GAJames, MJJones, EVKaroutchi, GIKenny, PWMorley, ADOldham, KRankine, NRyan, DWells, SLWood, LAugustin, MKrapp, SSimader, HSteinbacher, S Dipeptidyl nitrile inhibitors of Cathepsin L. Bioorg Med Chem Lett19:4280-3 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Procathepsin L [114-333,T223A]
Name:Procathepsin L [114-333,T223A]
Synonyms:CATL1_HUMAN | CTSL | CTSL1 | Cathepsin L
Type:Cysteine Protease
Mol. Mass.:24128.88
Organism:Homo sapiens (Human)
Description:P07711[114-333,T223A]
Residue:220
Sequence:
APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQ
GNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDAGFVDIPKQEK
ALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNN
KYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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BDBM31978
BDBM22047
NameBDBM31978
Synonyms:Dipeptidyl nitrile inhibitor, 11
TypeSmall organic molecule
Emp. Form.C20H20ClN3O2
Mol. Mass.369.845
SMILESCc1ccc(C)c(c1)C(=O)N[C@@H](Cc1cccc(Cl)c1)C(=O)NCC#N |r|
Structure
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