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TargetHeat shock 70 kDa protein 1A
LigandBDBM32377
Substrate/CompetitorBDBM32369
Meas. Tech.HSP70 Fluorescence Polarization Assay
pH7.4±n/a
Temperature296.15±n/a K
IC50 2400±n/a nM
Citation Williamson, DSBorgognoni, JClay, ADaniels, ZDokurno, PDrysdale, MJFoloppe, NFrancis, GLGraham, CJHowes, RMacias, ATMurray, JBParsons, RShaw, TSurgenor, AETerry, LWang, YWood, MMassey, AJ Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design. J Med Chem52:1510-3 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Heat shock 70 kDa protein 1A
Name:Heat shock 70 kDa protein 1A
Synonyms:HS71A_HUMAN | HSP70-1/HSP70-2 | HSP70.1 | HSP72 | HSPA1 | HSPA1A | HSX70 | Heat Shock 70kDa Protein 1 | Heat shock 70 kDa protein 1A/1B | Hsp70
Type:Chaperone
Mol. Mass.:70043.82
Organism:Homo sapiens (Human)
Description:n/a
Residue:641
Sequence:
MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVA
LNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEIS
SMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAA
IAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNH
FVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRA
RFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLN
KSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTI
PTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDI
DANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKN
ALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELE
QVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
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BDBM32377
BDBM32369
NameBDBM32377
Synonyms:adenosine-derived inhibitor (Grp78), 12 | adenosine-derived inhibitor, 11
TypeSmall organic molecule
Emp. Form.C24H24Cl2N6O4
Mol. Mass.531.391
SMILESNc1ncnc2n([C@@H]3O[C@H](COCc4ccccc4)[C@@H](O)[C@H]3O)c(NCc3ccc(Cl)c(Cl)c3)nc12 |r|
Structure
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