Reaction Details |
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Target | Heat shock protein HSP 90-beta |
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Ligand | BDBM33240 |
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Substrate/Competitor | BDBM15527 |
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Meas. Tech. | Fluorescence Polarization (FP) Assay |
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pH | 7.4±n/a |
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Temperature | 296.15±n/a K |
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IC50 | 29±n/a nM |
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Citation | Brough, PA; Barril, X; Borgognoni, J; Chene, P; Davies, NG; Davis, B; Drysdale, MJ; Dymock, B; Eccles, SA; Garcia-Echeverria, C; Fromont, C; Hayes, A; Hubbard, RE; Jordan, AM; Jensen, MR; Massey, A; Merrett, A; Padfield, A; Parsons, R; Radimerski, T; Raynaud, FI; Robertson, A; Roughley, SD; Schoepfer, J; Simmonite, H; Sharp, SY; Surgenor, A; Valenti, M; Walls, S; Webb, P; Wood, M; Workman, P; Wright, L Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone. J Med Chem52:4794-809 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Heat shock protein HSP 90-beta |
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Name: | Heat shock protein HSP 90-beta |
Synonyms: | HS90B_HUMAN | HSP 84 | HSP 90 | HSP90AB1 | HSP90B | HSPC2 | HSPCB | Heat Shock Protein 90 (Hsp90) | Heat shock protein HSP 90 (Hsp90) |
Type: | Molecular Chaperone |
Mol. Mass.: | 83229.45 |
Organism: | Homo sapiens (Human) |
Description: | P08238 |
Residue: | 724 |
Sequence: | MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT
DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG
ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE
DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE
YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA
EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ
KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG
LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA
NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE
TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM
EEVD
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BDBM33240 |
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BDBM15527 |
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Name | BDBM33240 |
Synonyms: | thieno[2,3-d]pyrimidine, 34g |
Type | Small organic molecule |
Emp. Form. | C17H15Cl2N5O3S |
Mol. Mass. | 440.304 |
SMILES | CCNC(=O)c1cc2c(nc(N)nc2s1)-c1cc(OCC(N)=O)c(Cl)cc1Cl |
Structure |
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