Reaction Details |
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Target | Genome polyprotein [1424-1463]/[1502-1685] |
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Ligand | BDBM33264 |
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Substrate/Competitor | BDBM33263 |
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Meas. Tech. | Protease Inhibition Assay |
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pH | 8.5±n/a |
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Temperature | 296.15±n/a K |
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Ki | 16000±2000 nM |
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Citation | Ganesh, VK; Muller, N; Judge, K; Luan, CH; Padmanabhan, R; Murthy, KH Identification and characterization of nonsubstrate based inhibitors of the essential dengue and West Nile virus proteases. Bioorg Med Chem13:257-64 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Genome polyprotein [1424-1463]/[1502-1685] |
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Name: | Genome polyprotein [1424-1463]/[1502-1685] |
Synonyms: | WNV CF40.Gly.NS3Pro | WNV NS2B(H):NS3 | West Nile Virus (WNV) NS2B-NS3 Protease |
Type: | Cofactor/Enzyme |
Mol. Mass.: | n/a |
Description: | It is the catalytically active recombinant WNV protease, consisting of a 40-residue component of cofactor NS2B tethered via a nonapeptide (G4SG4) to the N-terminal 184 residues of NS3. |
Components: | This complex has 2 components. |
Component 1 |
Name: | Genome polyprotein [1424-1463] |
Synonyms: | Flavivirin protease NS2B regulatory subunit | NS2B | POLG_WNV |
Type: | Cofactor Domain |
Mol. Mass.: | 4431.59 |
Organism: | West Nile virus (WNV) |
Description: | P06935[1424-1463] |
Residue: | 40 |
Sequence: | IERTADITWESDAEITGSSERVDVRLDDDGNFQLMNDPGA
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Component 2 |
Name: | Genome polyprotein [1502-1685] |
Synonyms: | Flavivirin protease NS3 catalytic subunit | NS3 | POLG_WNV |
Type: | Catalytic Subunit |
Mol. Mass.: | 19839.27 |
Organism: | West Nile virus (WNV) |
Description: | P06935[1502-1685] |
Residue: | 184 |
Sequence: | GGVLWDTPSPKEYKKGDTTTGVYRIMTRGLLGSYQAGAGVMVEGVFHTLWHTTKGAALMS
GEGRLDPYWGSVKEDRLCYGGPWKLQHKWNGHDEVQMIVVEPGKNVKNVQTKPGVFKTPE
GEIGAVTLDYPTGTSGSPIVDKNGDVIGLYGNGVIMPNGSYISAIVQGERMEEPAPAGFE
PEML
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BDBM33264 |
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BDBM33263 |
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Name | BDBM33264 |
Synonyms: | guanidine, 4 |
Type | Small organic molecule |
Emp. Form. | C9H9N5O |
Mol. Mass. | 203.2007 |
SMILES | [#7]\[#6](-[#7])=[#7]\[#7]=[#6]-1-[#6](=O)-[#7]-c2ccccc-12 |w:4.3| |
Structure |
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