| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 3 |
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| Ligand | BDBM33282 |
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| Substrate/Competitor | BDBM10856 |
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| Meas. Tech. | CA Inhibition Assay |
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| pH | 7.5±n/a |
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| Temperature | 296.15±n/a K |
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| Ki | 1206±n/a nM |
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| Citation |  Vitale, RM; Alterio, V; Innocenti, A; Winum, JY; Monti, SM; De Simone, G; Supuran, CT Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors. J Med Chem52:5990-8 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Carbonic anhydrase 3 |
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| Name: | Carbonic anhydrase 3 |
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| Synonyms: | CA-III | CA3 | CAH3_HUMAN | Carbonate dehydratase III | Carbonic Anhydrase III | Carbonic anhydrase | Carbonic anhydrase 3 (CA III) | Carbonic anhydrase III (CA III) |
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| Type: | Enzyme |
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| Mol. Mass.: | 29562.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human cloned isozyme. |
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| Residue: | 260 |
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| Sequence: | MAKEWGYASHNGPDHWHELFPNAKGENQSPVELHTKDIRHDPSLQPWSVSYDGGSAKTIL
NNGKTCRVVFDDTYDRSMLRGGPLPGPYRLRQFHLHWGSSDDHGSEHTVDGVKYAAELHL
VHWNPKYNTFKEALKQRDGIAVIGIFLKIGHENGEFQIFLDALDKIKTKGKEAPFTKFDP
SCLFPACRDYWTYQGSFTTPPCEECIVWLLLKEPMTVSSDQMAKLRSLLSSAENEPPVPL
VSNWRPPQPINNRVVRASFK
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| BDBM33282 |
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| BDBM10856 |
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| Name | BDBM33282 |
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| Synonyms: | CHEMBL171476 | bis-sulfamate, 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H24N2O6S2 |
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| Mol. Mass. | 332.437 |
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| SMILES | NS(=O)(=O)OCCCCCCCCCCOS(N)(=O)=O |
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| Structure | 
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