| Reaction Details |
|---|
 | Report a problem with these data |
| Target | DNA polymerase beta |
|---|
| Ligand | BDBM33386 |
|---|
| Substrate/Competitor | DNA template-primer |
|---|
| Meas. Tech. | DNA Polymerase Assay |
|---|
| pH | 7.5±n/a |
|---|
| Temperature | 310.15±n/a K |
|---|
| IC50 | 35000±n/a nM |
|---|
| Citation |  Kuramochi, K; Fukudome, K; Kuriyama, I; Takeuchi, T; Sato, Y; Kamisuki, S; Tsubaki, K; Sugawara, F; Yoshida, H; Mizushina, Y Synthesis and structure-activity relationships of dehydroaltenusin derivatives as selective DNA polymerase alpha inhibitors. Bioorg Med Chem17:7227-38 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| DNA polymerase beta |
|---|
| Name: | DNA polymerase beta |
|---|
| Synonyms: | DNA Polymerase beta | DPOLB_RAT | Polb |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 38334.34 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1361926 |
|---|
| Residue: | 335 |
|---|
| Sequence: | MSKRKAPQETLNGGITDMLVELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAK
KLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVTGIGPSAARKLVDEGIK
TLEDLRKNEDKLNHHQRIGLKYFEDFEKRIPREEMLQMQDIVLNEVKKLDPEYIATVCGS
FRRGAESSGDMDVLLTHPNFTSESSKQPKLLHRVVEQLQKVRFITDTLSKGETKFMGVCQ
LPSENDENEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRP
LGVTGVAGEPLPVDSEQDIFDYIQWRYREPKDRSE
|
|
|
|---|
| BDBM33386 |
|---|
| DNA template-primer |
|---|
| Name: | DNA template-primer |
|---|
| Synonyms: | poly(dA)/oligo(dT)(12Â?1), A/T = 2/1 |
|---|
| Type: | Duplex DNA |
|---|
| Mol. Mass.: | 358.43 |
|---|
| Organism: | n/a |
|---|
| Description: | [3H]-dTTP as co-substrate. |
|---|
| Residue: | 3 |
|---|
| Sequence: | |
|---|
Search and Browse
