Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM33406 |
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Substrate/Competitor | BDBM18044 |
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Meas. Tech. | Phosphotyrosine (PY) ELISA |
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IC50 | 62700±n/a nM |
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Citation | Gangjee, A; Li, W; Lin, L; Zeng, Y; Ihnat, M; Warnke, LA; Green, DW; Cody, V; Pace, J; Queener, SF Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors. Bioorg Med Chem17:7324-36 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21453.99 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human DHFR. |
Residue: | 187 |
Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM33406 |
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BDBM18044 |
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Name | BDBM33406 |
Synonyms: | 2,4-diaminofuro[2,3-d]pyrimidine, 12 |
Type | Small organic molecule |
Emp. Form. | C19H24N4O2 |
Mol. Mass. | 340.4195 |
SMILES | COc1ccccc1C(CC(C)C)Cc1coc2nc(N)nc(N)c12 |
Structure |
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