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TargetDihydrofolate reductase
LigandBDBM33396
Substrate/CompetitorBDBM18044
Meas. Tech.Phosphotyrosine (PY) ELISA
IC50 7920±n/a nM
Citation Gangjee, ALi, WLin, LZeng, YIhnat, MWarnke, LAGreen, DWCody, VPace, JQueener, SF Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors. Bioorg Med Chem17:7324-36 (2009) [PubMed]  Article
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Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DYR_MOUSE | Dhfr
Type:Enzyme
Mol. Mass.:21608.82
Organism:Mus musculus (Mouse)
Description:n/a
Residue:187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKF
EVYEKKD
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BDBM33396
BDBM18044
NameBDBM33396
Synonyms:2,4-diaminofuro[2,3-d]pyrimidine, 2 | E/Z ratio=2:1
TypeSmall organic molecule
Emp. Form.C18H20N4O2
Mol. Mass.324.377
SMILESCCC\C(=C\c1coc2nc(N)nc(N)c12)c1ccccc1OC
Structure
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