Reaction Details |
| Report a problem with these data |
Target | Dihydrofolate reductase |
---|
Ligand | BDBM33396 |
---|
Substrate/Competitor | BDBM18044 |
---|
Meas. Tech. | Phosphotyrosine (PY) ELISA |
---|
IC50 | 7920±n/a nM |
---|
Citation | Gangjee, A; Li, W; Lin, L; Zeng, Y; Ihnat, M; Warnke, LA; Green, DW; Cody, V; Pace, J; Queener, SF Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors. Bioorg Med Chem17:7324-36 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Dihydrofolate reductase |
---|
Name: | Dihydrofolate reductase |
Synonyms: | DYR_MOUSE | Dhfr |
Type: | Enzyme |
Mol. Mass.: | 21608.82 |
Organism: | Mus musculus (Mouse) |
Description: | n/a |
Residue: | 187 |
Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKF
EVYEKKD
|
|
|
BDBM33396 |
---|
BDBM18044 |
---|
Name | BDBM33396 |
Synonyms: | 2,4-diaminofuro[2,3-d]pyrimidine, 2 | E/Z ratio=2:1 |
Type | Small organic molecule |
Emp. Form. | C18H20N4O2 |
Mol. Mass. | 324.377 |
SMILES | CCC\C(=C\c1coc2nc(N)nc(N)c12)c1ccccc1OC |
Structure |
|