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TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S]
LigandBDBM33959
Substrate/CompetitorRNA/DNA hybrid
Meas. Tech.Assay of RT RNH Activity
pH8±n/a
Temperature310.15±n/a K
IC50 5000±n/a nM
Citation Himmel, DMSarafianos, SGDharmasena, SHossain, MMMcCoy-Simandle, KIlina, TClark, ADKnight, JLJulias, JGClark, PKKrogh-Jespersen, KLevy, RMHughes, SHParniak, MAArnold, E HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site. ACS Chem Biol1:702-12 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Gag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S]
Name:Gag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S]
Synonyms:HIV-1 Reverse Transcriptase RNase H
Type:Protein Complex
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Gag-Pol polyprotein [600-1151,C879S]
Synonyms:HIV-1 Reverse Transcriptase RNase H Chain A | POL_HV1B1 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:63584.38
Organism:Human immunodeficiency virus type 1
Description:P03366[600-1151,C879S]
Residue:552
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLSKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVPLTNTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLV
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  Blast E-value cutoff:
Component 2
Name:Gag-Pol polyprotein [600-1028,C879S]
Synonyms:HIV-1 Reverse Transcriptase RNase H Chain B | POL_HV1B1 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:50093.74
Organism:Human immunodeficiency virus type 1
Description:P03366[600-1028,C879S]
Residue:429
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLSKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQL
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  Blast E-value cutoff:
BDBM33959
RNA/DNA hybrid
Name:RNA/DNA hybrid
Synonyms:n/a
Type:fluorescein-labeled RNA annealed to DNA
Mol. Mass.:2134.40
Organism:n/a
Description:It is a 18-nucleotide 3-fluorescein-labeled RNA annealed to a complementary 18-nucleotide 5-Dabcyl-modified DNA.
Residue:23
Sequence:
5-GAU CUG AGC CUG GGA GCU-fluorescein-3