Reaction Details |
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Target | Gag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S] |
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Ligand | BDBM33959 |
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Substrate/Competitor | poly(rA)-oligo(dT)(12-18) |
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Meas. Tech. | Assay of RT RNA-Dependent DNA Polymerase (RDDP) Activity |
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pH | 7.8±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 500±n/a nM |
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Citation | Himmel, DM; Sarafianos, SG; Dharmasena, S; Hossain, MM; McCoy-Simandle, K; Ilina, T; Clark, AD; Knight, JL; Julias, JG; Clark, PK; Krogh-Jespersen, K; Levy, RM; Hughes, SH; Parniak, MA; Arnold, E HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site. ACS Chem Biol1:702-12 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Gag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S] |
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Name: | Gag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S] |
Synonyms: | HIV-1 Reverse Transcriptase RNase H |
Type: | Protein Complex |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Gag-Pol polyprotein [600-1151,C879S] |
Synonyms: | HIV-1 Reverse Transcriptase RNase H Chain A | POL_HV1B1 | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 63584.38 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P03366[600-1151,C879S] |
Residue: | 552 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLSKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVPLTNTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLV
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Component 2 |
Name: | Gag-Pol polyprotein [600-1028,C879S] |
Synonyms: | HIV-1 Reverse Transcriptase RNase H Chain B | POL_HV1B1 | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 50093.74 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P03366[600-1028,C879S] |
Residue: | 429 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLSKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQL
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BDBM33959 |
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poly(rA)-oligo(dT)(12-18) |
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Name: | poly(rA)-oligo(dT)(12-18) |
Synonyms: | homopolymeric template-primer |
Type: | RNA/DNA Duplex |
Mol. Mass.: | 358.43 |
Organism: | n/a |
Description: | [3H]-TTP as co-substrate. |
Residue: | 3 |
Sequence: | |