Reaction Details |
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Target | Gag-Pol polyprotein [600-1028,V705A,Y780C,C879S]/[600-1151,V705A,Y780C,C879S] |
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Ligand | BDBM2483 |
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Substrate/Competitor | RNA/DNA hybrid |
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Meas. Tech. | Assay of RT RNH Activity |
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Citation | Himmel, DM; Sarafianos, SG; Dharmasena, S; Hossain, MM; McCoy-Simandle, K; Ilina, T; Clark, AD; Knight, JL; Julias, JG; Clark, PK; Krogh-Jespersen, K; Levy, RM; Hughes, SH; Parniak, MA; Arnold, E HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site. ACS Chem Biol1:702-12 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Gag-Pol polyprotein [600-1028,V705A,Y780C,C879S]/[600-1151,V705A,Y780C,C879S] |
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Name: | Gag-Pol polyprotein [600-1028,V705A,Y780C,C879S]/[600-1151,V705A,Y780C,C879S] |
Synonyms: | HIV-1 Reverse Transcriptase RNase H Mutant (V106A/Y181C) |
Type: | Protein Complex |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Gag-Pol polyprotein [600-1151,V705A,Y780C,C879S] |
Synonyms: | HIV-1 Reverse Transcriptase RNase H Mutant (V106A/Y181C) Chain A | POL_HV1B1 | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 63496.29 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P03366[600-1151,V705A,Y780C,C879S] |
Residue: | 552 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSATVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI
CQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLSKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVPLTNTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLV
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Component 2 |
Name: | Gag-Pol polyprotein [600-1028,V705A,Y780C,C879S] |
Synonyms: | HIV-1 Reverse Transcriptase RNase H Mutant (V106A/Y181C) Chain B | POL_HV1B1 | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 50005.66 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P03366[600-1028,V705A,Y780C,C879S] |
Residue: | 429 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSATVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI
CQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLSKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQL
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BDBM2483 |
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RNA/DNA hybrid |
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Name: | RNA/DNA hybrid |
Synonyms: | n/a |
Type: | fluorescein-labeled RNA annealed to DNA |
Mol. Mass.: | 2134.40 |
Organism: | n/a |
Description: | It is a 18-nucleotide 3-fluorescein-labeled RNA annealed to a complementary 18-nucleotide 5-Dabcyl-modified DNA. |
Residue: | 23 |
Sequence: | 5-GAU CUG AGC CUG GGA GCU-fluorescein-3
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