Reaction Details |
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Target | Protein kinase C delta type |
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Ligand | BDBM2683 |
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Substrate/Competitor | Peptide Substrate |
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Meas. Tech. | Protein Kinase Assays |
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pH | 7.4±n/a |
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Temperature | 296.15±n/a K |
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IC50 | 8.7±1.5 nM |
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Citation | Wagner, J; von Matt, P; Sedrani, R; Albert, R; Cooke, N; Ehrhardt, C; Geiser, M; Rummel, G; Stark, W; Strauss, A; Cowan-Jacob, SW; Beerli, C; Weckbecker, G; Evenou, JP; Zenke, G; Cottens, S Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes. J Med Chem52:6193-6 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Protein kinase C delta type |
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Name: | Protein kinase C delta type |
Synonyms: | KPCD_HUMAN | PKC delta | PKCD | PRKCD | Protein Kinase C- delta | Protein kinase C, PKC; classical/novel | nPKC-delta |
Type: | Enzyme |
Mol. Mass.: | 77516.79 |
Organism: | Homo sapiens (Human) |
Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells |
Residue: | 676 |
Sequence: | MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD
AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY
FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW
GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS
PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR
RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF
GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK
DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL
LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE
MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH
PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF
AGFSFVNPKFEHLLED
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BDBM2683 |
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Peptide Substrate |
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Name: | Peptide Substrate |
Synonyms: | biotinylated tridecapeptide substrate |
Type: | Peptide |
Mol. Mass.: | 1564.86 |
Organism: | n/a |
Description: | n/a |
Residue: | 13 |
Sequence: | |