Ki Summary

Reaction Details

Report a problem with these data

Target

Casein kinase II subunit alpha

Ligand

BDBM34046

Substrate/Competitor

CK-2 Peptide Substrate

Meas. Tech.

CK2 Phosphorylation Assay

7.5±n/a

Temperature

310.15±n/a K

19±n/a nM

Citation

Gianoncelli, A; Cozza, G; Orzeszko, A; Meggio, F; Kazimierczuk, Z; Pinna, LA Tetraiodobenzimidazoles are potent inhibitors of protein kinase CK2. Bioorg Med Chem17:7281-9 (2009) [PubMed] Article

More Info.:

Get all data from this article, Inhibition_Run data, Solution Info, Assay Method

Casein kinase II subunit alpha

Name:

Casein kinase II subunit alpha

Synonyms:

CSK21_RAT | Casein Kinase II | Csnk2a1

Type:

Enzyme Subunit

Mol. Mass.:

45081.00

Organism:

Rattus norvegicus (Rat)

Description:

Native CK2 purified from rat liver was used in enzyme phosphorylation assay.

Residue:

391

Sequence:

MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT
NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD
FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE
FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD
QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF
LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMSSAGMAGGSTPVSSANMMSGISSVPT
PSPLGPLAGSPVIAAANSLGIPVPAAAGAQQ

BDBM34046

CK-2 Peptide Substrate

Name:

CK-2 Peptide Substrate

Synonyms:

n/a

Type:

Peptide

Mol. Mass.:

1446.31

Organism:

n/a

Description:

n/a

Residue:

Sequence:

RRRADDSDDDDD