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TargetSerine/threonine-protein kinase Chk2 [209-531,Q209M]
LigandBDBM34063
Substrate/CompetitorHistone H1
Meas. Tech.In Vitro Protein Kinase Assay
pH7.5±n/a
Temperature303.15±n/a K
IC50 240±n/a nM
Citation Jobson, AG; Cardellina, JH; Scudiero, D; Kondapaka, S; Zhang, H; Kim, H; Shoemaker, R; Pommier, Y Identification of a Bis-guanylhydrazone [4,4'-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase. Mol Pharmacol72:876-84 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Serine/threonine-protein kinase Chk2 [209-531,Q209M]
Name:Serine/threonine-protein kinase Chk2 [209-531,Q209M]
Synonyms:CDS1 | CHEK2 | CHK2 | CHK2_HUMAN | Checkpoint Kinase (Chk2) | Checkpoint Kinase 2 | RAD53
Type:Serine/threonine-protein kinase
Mol. Mass.:36511.81
Organism:Homo sapiens (Human)
Description:O96017[209-531,Q209M]
Residue:323
Sequence:
MSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPAL
NVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYF
YQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTP
TYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFI
PEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTAL
PQVLAQPSTSRKRPREGEAEGAE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM34063
Histone H1
Name:Histone H1
Synonyms:n/a
Type:Other Protein Type
Mol. Mass.:358.43
Organism:Bos taurus (bovine)
Description:n/a
Residue:3
Sequence:
n/a