| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Chk2 [209-531,Q209M] |
|---|
| Ligand | BDBM34067 |
|---|
| Substrate/Competitor | Fam-CHK2tide |
|---|
| Meas. Tech. | IMAP High-Throughput Screening |
|---|
| pH | 7.2±n/a |
|---|
| Temperature | 296.15±n/a K |
|---|
| IC50 | >20000±n/a nM |
|---|
| Citation |  Jobson, AG; Cardellina, JH; Scudiero, D; Kondapaka, S; Zhang, H; Kim, H; Shoemaker, R; Pommier, Y Identification of a Bis-guanylhydrazone [4,4'-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase. Mol Pharmacol72:876-84 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
|---|
| |
| Serine/threonine-protein kinase Chk2 [209-531,Q209M] |
|---|
| Name: | Serine/threonine-protein kinase Chk2 [209-531,Q209M] |
|---|
| Synonyms: | CDS1 | CHEK2 | CHK2 | CHK2_HUMAN | Checkpoint Kinase (Chk2) | Checkpoint Kinase 2 | RAD53 |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 36511.81 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O96017[209-531,Q209M] |
|---|
| Residue: | 323 |
|---|
| Sequence: | MSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPAL
NVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYF
YQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTP
TYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFI
PEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTAL
PQVLAQPSTSRKRPREGEAEGAE
|
|
|
|---|
| BDBM34067 |
|---|
| Fam-CHK2tide |
|---|
| Name: | Fam-CHK2tide |
|---|
| Synonyms: | n/a |
|---|
| Type: | fluorescent-labeled peptide |
|---|
| Mol. Mass.: | 2356.22 |
|---|
| Organism: | n/a |
|---|
| Description: | n/a |
|---|
| Residue: | 19 |
|---|
| Sequence: | |
|---|
Search and Browse
