| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase |
|---|
| Ligand | BDBM10875 |
|---|
| Substrate/Competitor | BDBM10856 |
|---|
| Meas. Tech. | CA Inhibition Assay |
|---|
| Ki | 379±n/a nM |
|---|
| Citation |  Innocenti, A; Hall, RA; Schlicker, C; Scozzafava, A; Steegborn, C; Mühlschlegel, FA; Supuran, CT Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides. Bioorg Med Chem17:4503-9 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Carbonic anhydrase |
|---|
| Name: | Carbonic anhydrase |
|---|
| Synonyms: | Carbonic Anhydrase 2 (Can2) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 26594.37 |
|---|
| Organism: | Cryptococcus neoformans var. grubii (Filobasidiella neoformans var. grubii) |
|---|
| Description: | n/a |
|---|
| Residue: | 239 |
|---|
| Sequence: | MPFHAEPLKPSDEIDMDLGHSVAAQKFKEIREVLEGNRYWARKVTSEEPEFMAEQVKGQA
PNFLWIGCADSRVPEVTIMARKPGDVFVQRNVANQFKPEDDSSQALLNYAIMNVGVTHVM
VVGHTGCGGCIAAFDQPLPTEENPGGTPLVRYLEPIIRLKHSLPEGSDVNDLIKENVKMA
VKNVVNSPTIQGAWEQARKGEFREVFVHGWLYDLSTGNIVDLNVTQGPHPFVDDRVPRA
|
|
|
|---|
| BDBM10875 |
|---|
| BDBM10856 |
|---|
| Name | BDBM10875 |
|---|
| Synonyms: | 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide | CHEMBL360356 | Chlorzolamide, CHL | JMC522226 Compound 19 | JMC523116 Compound 19 | aromatic/heteroaromatic sulfonamide 20 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C8H6ClN3O2S2 |
|---|
| Mol. Mass. | 275.735 |
|---|
| SMILES | NS(=O)(=O)c1nnc(s1)-c1ccccc1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
