Reaction Details | |||
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Report a problem with these data | |||
Target | Tyrosine-protein kinase Mer | ||
Ligand | BDBM350843 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
IC50 | 0.730±n/a nM | ||
Citation | Wang, X; Zhang, W; Frye, S Therapeutic uses of selected pyrrolopyrimidine compounds with anti-mer tyrosine kinase activity US Patent US10004755 Publication Date 6/26/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase Mer | |||
Name: | Tyrosine-protein kinase Mer | ||
Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
Type: | PROTEIN | ||
Mol. Mass.: | 110234.77 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1498723 | ||
Residue: | 999 | ||
Sequence: |
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BDBM350843 | |||
n/a | |||
Name | BDBM350843 | ||
Synonyms: | UNC1971A | US10004755, Compound UNC1971A | US9795606, B2 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H35FN6O3S | ||
Mol. Mass. | 530.658 | ||
SMILES | CCCCNc1ncc2c(cn(C3CC[C@H](N)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCOCC1 |r,wU:11.11,wD:15.15,(-8.43,-2.68,;-7.1,-1.91,;-5.76,-2.68,;-4.43,-1.91,;-3.09,-2.68,;-1.76,-1.91,;-1.76,-.37,;-.43,.4,;.91,-.37,;2.37,.1,;3.28,-1.14,;2.37,-2.39,;2.77,-3.88,;4.26,-4.27,;4.66,-5.76,;3.57,-6.85,;3.97,-8.34,;2.08,-6.45,;1.68,-4.96,;.91,-1.91,;-.43,-2.68,;2.77,1.59,;4.26,1.99,;4.66,3.48,;3.57,4.57,;2.08,4.17,;.99,5.26,;1.68,2.68,;3.97,6.05,;2.48,6.45,;3.57,7.54,;5.45,6.45,;6.54,5.36,;8.03,5.76,;8.43,7.25,;7.34,8.34,;5.85,7.94,)| | ||
Structure |