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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM350861 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| IC50 | 0.970±n/a nM | ||
| Citation |  Wang, X; Zhang, W; Frye, S Therapeutic uses of selected pyrrolopyrimidine compounds with anti-mer tyrosine kinase activity US Patent US10004755 Publication Date 6/26/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
| ||
| BDBM350861 | |||
| n/a | |||
| Name | BDBM350861 | ||
| Synonyms: | UNC2371A | US10004755, Compound UNC2371A | US9795606, B20 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H40N6O | ||
| Mol. Mass. | 488.6675 | ||
| SMILES | CN1CCN(Cc2ccc(cc2)-c2cn(C3CC[C@H](O)CC3)c3nc(NCCC4CC4)ncc23)CC1 |r,wU:14.15,wD:18.19,(9.28,7.65,;7.79,7.25,;7.39,5.76,;5.9,5.36,;4.81,6.45,;3.33,6.05,;2.93,4.57,;4.02,3.48,;3.62,1.99,;2.13,1.59,;1.04,2.68,;1.44,4.17,;1.73,.1,;2.64,-1.14,;1.73,-2.39,;2.13,-3.88,;3.62,-4.27,;4.02,-5.76,;2.93,-6.85,;3.33,-8.34,;1.44,-6.45,;1.04,-4.96,;.27,-1.91,;-1.07,-2.68,;-2.4,-1.91,;-3.73,-2.68,;-5.07,-1.91,;-6.4,-2.68,;-7.74,-1.91,;-8.51,-.58,;-9.28,-1.91,;-2.4,-.37,;-1.07,.4,;.27,-.37,;5.21,7.94,;6.7,8.34,)| | ||
| Structure | 
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