| Reaction Details |
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 | Report a problem with these data |
| Target | Oxysterols receptor LXR-beta [154-461] |
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| Ligand | BDBM35099 |
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| Substrate/Competitor | BDBM19993 |
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| Meas. Tech. | LXRbeta Binding Assay (IC50) and LAFbeta Functional Assay (EC50) |
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| pH | 7.4±n/a |
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| Temperature | 277.15±n/a K |
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| IC50 | 2.5±n/a nM |
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| EC50 | 108±n/a nM |
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| Comments | Efficacy=84%. |
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| Citation |  Bernotas, RC; Kaufman, DH; Singhaus, RR; Ullrich, J; Unwalla, R; Quinet, E; Nambi, P; Wilhelmsson, A; Goos-Nilsson, A; Wrobel, J 4-(3-aryloxyaryl)quinoline alcohols are liver X receptor agonists. Bioorg Med Chem17:8086-92 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Oxysterols receptor LXR-beta [154-461] |
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| Name: | Oxysterols receptor LXR-beta [154-461] |
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| Synonyms: | LXRB | Liver X Receptor beta (LXR-beta) | NER | NR1H2 | NR1H2_HUMAN | Nuclear orphan receptor LXR-beta | Nuclear receptor NER | Nuclear receptor subfamily 1 group H member 2 | Oxysterols receptor LXR-beta | UNR | Ubiquitously-expressed nuclear receptor |
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| Type: | Receptor |
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| Mol. Mass.: | 34695.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | LXR beta ligand binding domain (amino acid residues 154-461) with an N-terminal biotinylation tag expressed in E.coli, was used for the binding assays. |
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| Residue: | 308 |
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| Sequence: | MREQCVLSEEQIRKKKIRKQQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGS
GEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFT
ELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKD
FTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRV
EALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPL
LSEIWDVH
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| BDBM35099 |
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| BDBM19993 |
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| Name | BDBM35099 |
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| Synonyms: | biarylether alcohol quinoline, 5i |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22ClNO2 |
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| Mol. Mass. | 403.901 |
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| SMILES | Cc1cnc2c(Cl)cccc2c1-c1cccc(Oc2cccc(c2)C(C)(C)O)c1 |
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| Structure | 
|
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