Reaction Details |
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Target | Oxysterols receptor LXR-beta [154-461] |
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Ligand | BDBM35113 |
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Substrate/Competitor | BDBM19993 |
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Meas. Tech. | LXR Binding Assay and hLXR Reporter Assay |
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pH | 7.4±n/a |
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Temperature | 277.15±n/a K |
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IC50 | 3±n/a nM |
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Citation | Bernotas, RC; Singhaus, RR; Kaufman, DH; Ullrich, J; Fletcher, H; Quinet, E; Nambi, P; Unwalla, R; Wilhelmsson, A; Goos-Nilsson, A; Farnegardh, M; Wrobel, J Biarylether amide quinolines as liver X receptor agonists. Bioorg Med Chem17:1663-70 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Oxysterols receptor LXR-beta [154-461] |
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Name: | Oxysterols receptor LXR-beta [154-461] |
Synonyms: | LXRB | Liver X Receptor beta (LXR-beta) | NER | NR1H2 | NR1H2_HUMAN | Nuclear orphan receptor LXR-beta | Nuclear receptor NER | Nuclear receptor subfamily 1 group H member 2 | Oxysterols receptor LXR-beta | UNR | Ubiquitously-expressed nuclear receptor |
Type: | Receptor |
Mol. Mass.: | 34695.52 |
Organism: | Homo sapiens (Human) |
Description: | LXR beta ligand binding domain (amino acid residues 154-461) with an N-terminal biotinylation tag expressed in E.coli, was used for the binding assays. |
Residue: | 308 |
Sequence: | MREQCVLSEEQIRKKKIRKQQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGS
GEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFT
ELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKD
FTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRV
EALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPL
LSEIWDVH
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BDBM35113 |
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BDBM19993 |
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Name | BDBM35113 |
Synonyms: | biarylether amide quinoline, 4n |
Type | Small organic molecule |
Emp. Form. | C27H23ClN2O2 |
Mol. Mass. | 442.937 |
SMILES | Cc1cnc2c(Cl)cccc2c1-c1cccc(Oc2cccc(c2)C(=O)N2CCCC2)c1 |
Structure |
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