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TargetQuinone reductase 1)
LigandBDBM35527
Substrate/CompetitorBDBM24778
Meas. Tech.Inhibition of NQO1 (With 2 uM BSA)
pH7.5±n/a
Temperature298.15±n/a K
IC50 38±2.1 nM
Citation Nolan KADoncaster JRDunstan MSScott KAFrenkel ADSiegel DRoss DBarnes JLevy CLeys DWhitehead RCStratford IJBryce RA Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1). J Med Chem 52:7142-56 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Quinone reductase 1)
Name:Quinone reductase 1)
Synonyms:Azoreductase | DT-diaphorase | Menadione reductase | NAD(P)H dehydrogenase [quinone] 1 | NAD(P)H:quinone oxidoreductase 1 | Phylloquinone reductase | QR1 | Quinone Reductase 1 | Quinone reductase 1)
Type:Homodimer
Mol. Mass.:30874.82
Organism:Homo sapiens (Human)
Description:n/a
Residue:274
Sequence:
MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL
KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERV
FIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFC
GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK
KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK
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BDBM35527
BDBM24778
NameBDBM35527
Synonyms:symmetric dicoumarol analogue, 3
TypeSmall organic molecule
Emp. Form.C21H16O8
Mol. Mass.396.3469
SMILESCOc1cccc2oc(=O)c(Cc3c(O)c4c(OC)cccc4oc3=O)c(O)c12
Structure
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