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TargetQuinone reductase 1)
LigandBDBM35541
Substrate/CompetitorBDBM24778
Meas. Tech.Inhibition of NQO1 (With 2 uM BSA)
pH7.5±n/a
IC50 2.5±n/a nM
Commentsextracted
Citation Nolan KADoncaster JRDunstan MSScott KAFrenkel ADSiegel DRoss DBarnes JLevy CLeys DWhitehead RCStratford IJBryce RA Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1). J Med Chem 52:7142-56 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Quinone reductase 1)
Name:Quinone reductase 1)
Synonyms:Azoreductase | DT-diaphorase | Menadione reductase | NAD(P)H dehydrogenase [quinone] 1 | NAD(P)H:quinone oxidoreductase 1 | Phylloquinone reductase | QR1 | Quinone Reductase 1 | Quinone reductase 1)
Type:Homodimer
Mol. Mass.:30874.82
Organism:Homo sapiens (Human)
Description:n/a
Residue:274
Sequence:
MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL
KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERV
FIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFC
GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK
KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK
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  Blast E-value cutoff:
BDBM35541
BDBM24778
NameBDBM35541
Synonyms:4-hydroxy-2H-chromen-2-one core, 17
TypeSmall organic molecule
Emp. Form.C22H18O3
Mol. Mass.330.3765
SMILESCc1cc2oc(=O)c(Cc3ccc4ccccc4c3)c(O)c2cc1C
Structure
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