Reaction Details |
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Target | Genome polyprotein [2420-2989,M2842K,R2963Q] |
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Ligand | BDBM35554 |
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Substrate/Competitor | poly(A)/oligo(U)18 |
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Meas. Tech. | HCV RNA-Dependent RNA Polymerase Assay (IC50) |
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pH | 7.5±n/a |
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Temperature | 296.15±n/a K |
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IC50 | >500±n/a nM |
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Citation | Ontoria, JM; Rydberg, EH; Di Marco, S; Tomei, L; Attenni, B; Malancona, S; Martin Hernando, JI; Gennari, N; Koch, U; Narjes, F; Rowley, M; Summa, V; Carroll, SS; Olsen, DB; De Francesco, R; Altamura, S; Migliaccio, G; Carfì, A Identification and Biological Evaluation of a Series of 1H-Benzo[de]isoquinoline-1,3(2H)-diones as Hepatitis C Virus NS5B Polymerase Inhibitors. J Med Chem52:5217-27 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Genome polyprotein [2420-2989,M2842K,R2963Q] |
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Name: | Genome polyprotein [2420-2989,M2842K,R2963Q] |
Synonyms: | HCV NS5B Polymerase Mutant (M423K) | POLG_HCVBK |
Type: | Mutant Enzyme |
Mol. Mass.: | 64280.74 |
Organism: | Hepatitis C virus genotype 1b (isolate BK) (HCV) |
Description: | P26663[2420-2989,M2842K,R2963Q] |
Residue: | 578 |
Sequence: | SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRSAGLRQKKVTFDRLQVL
DDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIH
SVWKDLLEDTVTPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVS
TLPQVVMGSSYGFQYSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIY
QCCDLAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAS
AACRAAKLQDCTMLVNGDDLVVICESAGTQEDAASLRVFTEAMTRYSAPPGDPPQPEYDL
ELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLW
ARKILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPG
EINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIP
AASQLDLSGWFVAGYSGGDIYHSLSRARPRLEHHHHHH
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BDBM35554 |
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poly(A)/oligo(U)18 |
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Name: | poly(A)/oligo(U)18 |
Synonyms: | n/a |
Type: | homopolymeric template/primer |
Mol. Mass.: | 358.43 |
Organism: | n/a |
Description: | UTP/3H-UTP as co-substrate. |
Residue: | 3 |
Sequence: | |