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TargetGenome polyprotein [2420-2989,M2842K,R2963Q]
LigandBDBM35554
Substrate/Competitorpoly(A)/oligo(U)18
Meas. Tech.HCV RNA-Dependent RNA Polymerase Assay (IC50)
pH7.5±n/a
Temperature296.15±n/a K
IC50>500±n/a nM
Citation Ontoria, JMRydberg, EHDi Marco, STomei, LAttenni, BMalancona, SMartin Hernando, JIGennari, NKoch, UNarjes, FRowley, MSumma, VCarroll, SSOlsen, DBDe Francesco, RAltamura, SMigliaccio, GCarfì, A Identification and Biological Evaluation of a Series of 1H-Benzo[de]isoquinoline-1,3(2H)-diones as Hepatitis C Virus NS5B Polymerase Inhibitors. J Med Chem52:5217-27 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Genome polyprotein [2420-2989,M2842K,R2963Q]
Name:Genome polyprotein [2420-2989,M2842K,R2963Q]
Synonyms:HCV NS5B Polymerase Mutant (M423K) | POLG_HCVBK
Type:Mutant Enzyme
Mol. Mass.:64280.74
Organism:Hepatitis C virus genotype 1b (isolate BK) (HCV)
Description:P26663[2420-2989,M2842K,R2963Q]
Residue:578
Sequence:
SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRSAGLRQKKVTFDRLQVL
DDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIH
SVWKDLLEDTVTPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVS
TLPQVVMGSSYGFQYSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIY
QCCDLAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAS
AACRAAKLQDCTMLVNGDDLVVICESAGTQEDAASLRVFTEAMTRYSAPPGDPPQPEYDL
ELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLW
ARKILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPG
EINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIP
AASQLDLSGWFVAGYSGGDIYHSLSRARPRLEHHHHHH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM35554
poly(A)/oligo(U)18
Name:poly(A)/oligo(U)18
Synonyms:n/a
Type:homopolymeric template/primer
Mol. Mass.:358.43
Organism:n/a
Description:UTP/3H-UTP as co-substrate.
Residue:3
Sequence:
n/a