| Reaction Details |
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 | Report a problem with these data |
| Target | Vasopressin V2 receptor |
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| Ligand | BDBM35723 |
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| Substrate/Competitor | BDBM35667 |
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| Meas. Tech. | Radioligand Binding Assay to HeLa Cells |
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| pH | 7.4±n/a |
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| Temperature | 277.15±n/a K |
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| IC50 | 3±n/a nM |
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| Citation |  Kondo, K; Ogawa, H; Yamashita, H; Miyamoto, H; Tanaka, M; Nakaya, K; Kitano, K; Yamamura, Y; Nakamura, S; Onogawa, T; Mori, T; Tominaga, M 7-Chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoyl-amino)benzoyl ]-2,3,4,5-tetrahydro-1H-1-benzazepine (OPC-41061): a potent, orally active nonpeptide arginine vasopressin V2 receptor antagonist. Bioorg Med Chem7:1743-54 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Vasopressin V2 receptor |
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| Name: | Vasopressin V2 receptor |
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| Synonyms: | ADHR | AVPR V2 | AVPR2 | Antidiuretic hormone receptor | DIR | DIR3 | Renal-type arginine vasopressin receptor | V2R | V2R_HUMAN | VASOPRESSIN V2 | Vasopressin V2 receptor | Vasopressin receptor |
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| Type: | Receptor |
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| Mol. Mass.: | 40295.28 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30518 |
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| Residue: | 371 |
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| Sequence: | MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLA
ALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQM
VGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQ
RNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGP
SERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEA
PLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTT
ASSSLAKDTSS
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| BDBM35723 |
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| BDBM35667 |
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| Name | BDBM35723 |
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| Synonyms: | CHEMBL344159 | N-[4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-3-methyl-phenyl]-2-methyl-benzamide | TOLVAPTAN | benzazepine derivative, 32 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H25ClN2O3 |
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| Mol. Mass. | 448.941 |
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| SMILES | Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(O)c3cc(Cl)ccc23)c(C)c1 |
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| Structure | 
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