Reaction Details |
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Target | Carbonic anhydrase 5A, mitochondrial |
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Ligand | BDBM35734 |
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Substrate/Competitor | BDBM10856 |
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Meas. Tech. | CA Inhibition Assay |
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Temperature | 298.15±n/a K |
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Ki | 8.6±n/a nM |
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Comments | extracted |
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Citation | Güzel, O; Innocenti, A; Scozzafava, A; Salman, A; Supuran, CT Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB. Bioorg Med Chem17:4894-9 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Carbonic anhydrase 5A, mitochondrial |
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Name: | Carbonic anhydrase 5A, mitochondrial |
Synonyms: | CA-VA | CA5 | CA5A | CAH5A_HUMAN | Carbonate dehydratase VA | Carbonic Anhydrase VA | Carbonic anhydrase 5A (CA VA) | Carbonic anhydrase 5A, mitochondrial | Carbonic anhydrase 5A, mitochondrial precursor | Carbonic anhydrase V | Carbonic anhydrase VA (CA VA) |
Type: | Enzyme |
Mol. Mass.: | 34755.54 |
Organism: | Homo sapiens (Human) |
Description: | Human (cloned) isozyme |
Residue: | 305 |
Sequence: | MLGRNTWKTSAFSFLVEQMWAPLWSRSMRPGRWCSQRSCAWQTSNNTLHPLWTVPVSVPG
GTRQSPINIQWRDSVYDPQLKPLRVSYEAASCLYIWNTGYLFQVEFDDATEASGISGGPL
ENHYRLKQFHFHWGAVNEGGSEHTVDGHAYPAELHLVHWNSVKYQNYKEAVVGENGLAVI
GVFLKLGAHHQTLQRLVDILPEIKHKDARAAMRPFDPSTLLPTCWDYWTYAGSLTTPPLT
ESVTWIIQKEPVEVAPSQLSAFRTLLFSALGEEEKMMVNNYRPLQPLMNRKVWASFQATN
EGTRS
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BDBM35734 |
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BDBM10856 |
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Name | BDBM35734 |
Synonyms: | sulfonamide deriv., 7b |
Type | Small organic molecule |
Emp. Form. | C15H16N2O3S |
Mol. Mass. | 304.364 |
SMILES | NS(=O)(=O)c1ccc(CNC(=O)Cc2ccccc2)cc1 |
Structure |
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