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TargetCarbonic anhydrase 5B, mitochondrial
LigandBDBM35740
Substrate/CompetitorBDBM10856
Meas. Tech.CA Inhibition Assay
Temperature298.15±n/a K
Ki 9.0±n/a nM
Commentsextracted
Citation Güzel, OInnocenti, AScozzafava, ASalman, ASupuran, CT Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB. Bioorg Med Chem17:4894-9 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Carbonic anhydrase 5B, mitochondrial
Name:Carbonic anhydrase 5B, mitochondrial
Synonyms:CA-VB | CA5B | CAH5B_HUMAN | Carbonate dehydratase VB | Carbonic Anhydrase VB | Carbonic anhydrase 5B (CA VB) | Carbonic anhydrase 5B, mitochondrial | Carbonic anhydrase 5B, mitochondrial precursor | Carbonic anhydrase V | Carbonic anhydrase VB (CA VB)
Type:Enzyme
Mol. Mass.:36440.83
Organism:Homo sapiens (Human)
Description:Human (cloned) isozyme
Residue:317
Sequence:
MVVMNSLRVILQASPGKLLWRKFQIPRFMPARPCSLYTCTYKTRNRALHPLWESVDLVPG
GDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVWNNGYSFLVEFEDSTDKSVIKGGPL
EHNYRLKQFHFHWGAIDAWGSEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVI
GVFLKLGKHHKELQKLVDTLPSIKHKDALVEFGSFDPSCLMPTCPDYWTYSGSLTTPPLS
ESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSFRHDY
VLNVQAKPKPATSQATP
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  Blast E-value cutoff:
BDBM35740
BDBM10856
NameBDBM35740
Synonyms:sulfonamide deriv., 7h
TypeSmall organic molecule
Emp. Form.C13H13N3O3S
Mol. Mass.291.326
SMILESNS(=O)(=O)c1ccc(NC(=O)Cc2ccncc2)cc1
Structure
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