Ki Summary

Reaction Details

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Target

Alpha-carbonic anhydrase domain-containing protein

Ligand

BDBM25914

Substrate/Competitor

BDBM10856

Meas. Tech.

CA Inhibition Assay

7.4±n/a

Temperature

298.15±n/a K

260±n/a nM

Citation

Güzel, O; Innocenti, A; Hall, RA; Scozzafava, A; Mühlschlegel, FA; Supuran, CT Carbonic anhydrase inhibitors. The nematode alpha-carbonic anhydrase of Caenorhabditis elegans CAH-4b is highly inhibited by 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides. Bioorg Med Chem17:3212-5 (2009) [PubMed] Article

More Info.:

Get all data from this article, Solution Info, Assay Method

Alpha-carbonic anhydrase domain-containing protein

Name:

Alpha-carbonic anhydrase domain-containing protein

Synonyms:

CAH-4b | alpha-Carbonic Anhydrase | ceCA

Type:

Enzyme

Mol. Mass.:

26169.24

Organism:

Caenorhabditis elegans

Description:

Q8WQD8

Residue:

235

Sequence:

MAAAQRQSPIDIVPQHVCCDTDVCKADALNIDYKSGDCCDVLVSEGGFLVNVKRNCGTFL
TANHLPSSKFALAQFHAHWGSNSKEGSEHFLDGKQLSGEVHFVFWNTSYESFNVALSKPD
GLAVVGVFLKEGKYNDNYHGLIDTVRKATGNATPIAMPKDFHIEHLLPSPDKREFVTYLG
SLTTPPYNECVIWTLFTEPVEVSFGQLNVLRNIIPANHRACQDRCDREIRSSFNF

BDBM25914

BDBM10856

Name

BDBM25914

Synonyms:

3-(2-bromophenyl)-2-(hydrazinecarbonyl)-1H-indole-5-sulfonamide | BMC173212 Compound 2j | indole sulfonamide, 8j

Type

Small organic molecule

Emp. Form.

C15H13BrN4O3S

Mol. Mass.

409.258

SMILES

NNC(=O)c1[nH]c2ccc(cc2c1-c1ccccc1Br)S(N)(=O)=O |(3.59,5.07,;2.05,5.07,;1.28,3.73,;2.05,2.4,;-.26,3.73,;-1.17,2.49,;-2.63,2.96,;-3.97,2.19,;-5.3,2.96,;-5.3,4.5,;-3.97,5.27,;-2.63,4.5,;-1.17,4.98,;-.69,6.44,;.79,6.86,;1.17,8.36,;.06,9.43,;-1.42,9.01,;-1.8,7.52,;-3.28,7.1,;-6.63,5.27,;-7.97,6.04,;-5.86,6.61,;-7.4,3.94,)|

Structure