Reaction Details | |||
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Target | Alpha-carbonic anhydrase domain-containing protein | ||
Ligand | BDBM25918 | ||
Substrate/Competitor | BDBM10856 | ||
Meas. Tech. | CA Inhibition Assay | ||
pH | 7.4±n/a | ||
Temperature | 298.15±n/a K | ||
Ki | 260±n/a nM | ||
Citation | Güzel, O; Innocenti, A; Hall, RA; Scozzafava, A; Mühlschlegel, FA; Supuran, CT Carbonic anhydrase inhibitors. The nematode alpha-carbonic anhydrase of Caenorhabditis elegans CAH-4b is highly inhibited by 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides. Bioorg Med Chem17:3212-5 (2009) [PubMed] Article | ||
More Info.: | Get all data from this article, Solution Info, Assay Method | ||
Alpha-carbonic anhydrase domain-containing protein | |||
Name: | Alpha-carbonic anhydrase domain-containing protein | ||
Synonyms: | CAH-4b | alpha-Carbonic Anhydrase | ceCA | ||
Type: | Enzyme | ||
Mol. Mass.: | 26169.24 | ||
Organism: | Caenorhabditis elegans | ||
Description: | Q8WQD8 | ||
Residue: | 235 | ||
Sequence: |
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BDBM25918 | |||
BDBM10856 | |||
Name | BDBM25918 | ||
Synonyms: | 2-(hydrazinecarbonyl)-3-(2,3,4,5,6-pentafluorophenyl)-1H-indole-5-sulfonamide | BMC173212 Compound 2n | indole sulfonamide, 8n | ||
Type | Small organic molecule | ||
Emp. Form. | C15H9F5N4O3S | ||
Mol. Mass. | 420.314 | ||
SMILES | NNC(=O)c1[nH]c2ccc(cc2c1-c1c(F)c(F)c(F)c(F)c1F)S(N)(=O)=O |(3.94,3.73,;2.61,4.5,;1.28,3.73,;2.05,2.4,;-.26,3.73,;-1.17,2.49,;-2.63,2.96,;-3.97,2.19,;-5.3,2.96,;-5.3,4.5,;-3.97,5.27,;-2.63,4.5,;-1.17,4.98,;-.69,6.44,;-1.8,7.52,;-3.28,7.1,;-1.42,9.01,;-2.52,10.08,;.06,9.43,;.44,10.92,;1.17,8.36,;2.65,8.78,;.79,6.86,;1.89,5.79,;-6.63,5.27,;-7.97,6.04,;-5.86,6.61,;-7.4,3.94,)| | ||
Structure |