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TargetDimer of Gag-Pol polyprotein [514-612]
LigandBDBM875
Substrate/CompetitorHIV Protease Peptide Substrate
Meas. Tech.Protease Inhibition Assay
pH4.7±n/a
Temperature310.15±n/a K
Ki 50±n/a nM
Citation Ettmayer, PBillich, AHecht, PRosenwirth, BGstach, H Paracyclophanes: a novel class of water-soluble inhibitors of HIV proteinase. J Med Chem39:3291-9 (1996) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Dimer of Gag-Pol polyprotein [514-612]
Name:Dimer of Gag-Pol polyprotein [514-612]
Synonyms:HIV-2 Protease
Type:Protein Complex
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Gag-Pol polyprotein [514-612]
Synonyms:HIV-2 Protease chain A | HIV-2 Protease chain B | POL_HV2RO | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10718.25
Organism:Human immunodeficiency virus type 2
Description:P04584[514-612]
Residue:99
Sequence:
PQFSLWKRPVVTAYIEGQPVEVLLDTGADDSIVAGIELGNNYSPKIVGGIGGFINTKEYK
NVEIEVLNKKVRATIMTGDTPINIFGRNILTALGMSLNL
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Component 2
Name:Gag-Pol polyprotein [514-612]
Synonyms:HIV-2 Protease chain A | HIV-2 Protease chain B | POL_HV2RO | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10718.25
Organism:Human immunodeficiency virus type 2
Description:P04584[514-612]
Residue:99
Sequence:
PQFSLWKRPVVTAYIEGQPVEVLLDTGADDSIVAGIELGNNYSPKIVGGIGGFINTKEYK
NVEIEVLNKKVRATIMTGDTPINIFGRNILTALGMSLNL
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BDBM875
HIV Protease Peptide Substrate
Name:HIV Protease Peptide Substrate
Synonyms:n/a
Type:Peptide
Mol. Mass.:3062.94
Organism:Synthesized
Description:n/a
Residue:29
Sequence:
H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2
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