Reaction Details |
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Target | Coagulation factor X |
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Ligand | BDBM35769 |
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Substrate/Competitor | BDBM12658 |
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Meas. Tech. | Enzyme Inhibition Assay |
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pH | 7.4±n/a |
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Temperature | 296.15±n/a K |
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IC50 | 1.4±n/a nM |
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Citation | Yoshikawa, K; Kobayashi, S; Nakamoto, Y; Haginoya, N; Komoriya, S; Yoshino, T; Nagata, T; Mochizuki, A; Watanabe, K; Suzuki, M; Kanno, H; Ohta, T Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: exploration of 6-6 fused rings as alternative S1 moieties. Bioorg Med Chem17:8221-33 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Coagulation factor X |
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Name: | Coagulation factor X |
Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
Type: | Enzyme |
Mol. Mass.: | 54726.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 488 |
Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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BDBM35769 |
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BDBM12658 |
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Name | BDBM35769 |
Synonyms: | cis-1,2-diaminocyclohexane derivative, 5j |
Type | Small organic molecule |
Emp. Form. | C26H30ClN7O4S |
Mol. Mass. | 572.079 |
SMILES | CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2nc3ccc(Cl)cc3c(=O)[nH]2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 |r| |
Structure |
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