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Reaction Details
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TargetCannabinoid receptor 1
LigandBDBM35879
Substrate/CompetitorBDBM35866
Meas. Tech.GTP-gamma-S Binding Assay
pH7.4±n/a
Temperature303.15±n/a K
IC50 1578±n/a nM
Citation Boström, JBerggren, KElebring, TGreasley, PJWilstermann, M Scaffold hopping, synthesis and structure-activity relationships of 5,6-diaryl-pyrazine-2-amide derivatives: a novel series of CB1 receptor antagonists. Bioorg Med Chem15:4077-84 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Cannabinoid receptor 1
Name:Cannabinoid receptor 1
Synonyms:CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:52868.96
Organism:Homo sapiens (Human)
Description:P21554
Residue:472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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  Blast E-value cutoff:
BDBM35879
BDBM35866
NameBDBM35879
Synonyms:5,6-bis-(2-chloro-phenyl)-pyrazine-2-carboxylicacid cyclohexylamide | 5,6-diaryl-pyrazine-2-amide derivative, 6e | CHEMBL376827
TypeSmall organic molecule
Emp. Form.C23H21Cl2N3O
Mol. Mass.426.338
SMILESClc1ccccc1-c1ncc(nc1-c1ccccc1Cl)C(=O)NC1CCCCC1
Structure
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