| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cannabinoid receptor 1 |
|---|
| Ligand | BDBM35880 |
|---|
| Substrate/Competitor | BDBM35866 |
|---|
| Meas. Tech. | GTP-gamma-S Binding Assay |
|---|
| pH | 7.4±n/a |
|---|
| Temperature | 303.15±n/a K |
|---|
| IC50 | 2790±n/a nM |
|---|
| Citation |  Boström, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M Scaffold hopping, synthesis and structure-activity relationships of 5,6-diaryl-pyrazine-2-amide derivatives: a novel series of CB1 receptor antagonists. Bioorg Med Chem15:4077-84 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
|---|
| |
| Cannabinoid receptor 1 |
|---|
| Name: | Cannabinoid receptor 1 |
|---|
| Synonyms: | CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain) |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 52868.96 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P21554 |
|---|
| Residue: | 472 |
|---|
| Sequence: | MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
|
|
|
|---|
| BDBM35880 |
|---|
| BDBM35866 |
|---|
| Name | BDBM35880 |
|---|
| Synonyms: | 5,6-diaryl-pyrazine-2-amide derivative, 7a | 5,6-diphenyl-pyrazine-2-carboxylic acid phenylamide | CHEMBL225241 | N,5,6-triphenylpyrazine-2-carboxamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H17N3O |
|---|
| Mol. Mass. | 351.4006 |
|---|
| SMILES | O=C(Nc1ccccc1)c1cnc(-c2ccccc2)c(n1)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
