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TargetTGF-beta receptor type-1
LigandBDBM35946
Substrate/CompetitorBDBM35940
Meas. Tech.Enzyme Compound Activity (IC50) and Cell Compound Activity (IC50/EC50)
pH7.4±n/a
Temperature296.15±n/a K
IC50 7±n/a nM
EC50 114±n/a nM
Citation Goldberg, FWWard, RAPowell, SJDebreczeni, JENorman, RARoberts, NJDishington, APGingell, HJWickson, KFRoberts, AL Rapid generation of a high quality lead for transforming growth factor-beta (TGF-beta) type I receptor (ALK5). J Med Chem52:7901-5 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
TGF-beta receptor type-1
Name:TGF-beta receptor type-1
Synonyms:ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I
Type:enzyme
Mol. Mass.:55968.24
Organism:Homo sapiens (Human)
Description:P36897
Residue:503
Sequence:
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPG
LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL
IYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER
SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE
GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS
ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI
HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA
ARLTALRIKKTLSQLSQQEGIKM
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  Blast E-value cutoff:
BDBM35946
BDBM35940
NameBDBM35946
Synonyms:4-pyridinoxy-2-anilinopyridine-based compound, 10
TypeSmall organic molecule
Emp. Form.C24H22N4O2
Mol. Mass.398.4571
SMILESCOc1ccccc1Nc1cc(Oc2cc(C)c(C)nc2-c2ccccn2)ccn1
Structure
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