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TargetDimer of Gag-Pol polyprotein [489-587]
LigandBDBM912
Substrate/CompetitorChromogenic Peptide Substrate
Meas. Tech.Protease Inhibition Assay
pH5.5±n/a
Temperature310.15±n/a K
Ki 3100±n/a nM
Citation Varney, MD; Appelt, K; Kalish, V; Reddy, MR; Tatlock, J; Palmer, CL; Romines, WH; Wu, BW; Musick, L Crystal-structure-based design and synthesis of novel C-terminal inhibitors of HIV protease. J Med Chem37:2274-84 (1994) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Dimer of Gag-Pol polyprotein [489-587]
Name:Dimer of Gag-Pol polyprotein [489-587]
Synonyms:HIV-1 Protease
Type:Protein Complex
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Gag-Pol polyprotein [489-587]
Synonyms:HIV protease | HIV-1 Protease (NY5-type sequence) | HIV-1 Protease chain A | HIV-1 Protease chain B | POL_HV1N5 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10822.21
Organism:Human immunodeficiency virus type 1
Description:P12497[489-587]
Residue:99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 2
Name:Gag-Pol polyprotein [489-587]
Synonyms:HIV protease | HIV-1 Protease (NY5-type sequence) | HIV-1 Protease chain A | HIV-1 Protease chain B | POL_HV1N5 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10822.21
Organism:Human immunodeficiency virus type 1
Description:P12497[489-587]
Residue:99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM912
Chromogenic Peptide Substrate
Name:Chromogenic Peptide Substrate
Synonyms:n/a
Type:Peptide
Mol. Mass.:3511.92
Organism:n/a
Description:n/a
Residue:33
Sequence:
His-Lys-Ala-Arg-Val-Leu-(p-NO2-Phe)-Glu-Ala-Nleu-Ser