| Reaction Details |
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 | Report a problem with these data |
| Target | Sliding-clamp-loader large/small subunit |
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| Ligand | BDBM36318 |
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| Substrate/Competitor | BDBM50118233 |
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| Meas. Tech. | colorimetric ATPase assay |
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| pH | 7.5±0 |
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| Temperature | 298.15±0 K |
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| Ki | 3.7e+4± 8e+3 nM |
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| Citation |  Eng, K; Scouten-Ponticelli, SK; Sutton, M; Berdis, A Selective Inhibition of DNA Replicase Assembly by a Non-natural Nucleotide: Exploiting the Structural Diversity of ATP-Binding Sites ACS Chem Biol5:183-94 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| Sliding-clamp-loader large/small subunit |
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| Name: | Sliding-clamp-loader large/small subunit |
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| Synonyms: | ATP-dependent clamp loaders gp44/62 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Sliding-clamp-loader large subunit |
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| Synonyms: | 44 | Clamp loader large subunit | Gene product 44 | LOADL_BPT4 | Sliding-clamp-loader gp44 subunit | gp44 |
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| Type: | n/a |
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| Mol. Mass.: | 35788.87 |
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| Organism: | Enterobacteria phage T4 (Bacteriophage T4) |
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| Description: | P04526 |
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| Residue: | 319 |
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| Sequence: | MITVNEKEHILEQKYRPSTIDECILPAFDKETFKSITSKGKIPHIILHSPSPGTGKTTVA
KALCHDVNADMMFVNGSDCKIDFVRGPLTNFASAASFDGRQKVIVIDEFDRSGLAESQRH
LRSFMEAYSSNCSIIITANNIDGIIKPLQSRCRVITFGQPTDEDKIEMMKQMIRRLTEIC
KHEGIAIADMKVVAALVKKNFPDFRKTIGELDSYSSKGVLDAGILSLVTNDRGAIDDVLE
SLKNKDVKQLRALAPKYAADYSWFVGKLAEEIYSRVTPQSIIRMYEIVGENNQYHGIAAN
TELHLAYLFIQLACEMQWK
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| Component 2 |
| Name: | Sliding-clamp-loader small subunit |
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| Synonyms: | 62 | Clamp loader small subunit | Gene product 62 | LOADS_BPT4 | Sliding-clamp-loader gp44 subunit | gp62 |
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| Type: | n/a |
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| Mol. Mass.: | 21366.49 |
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| Organism: | Enterobacteria phage T4 (Bacteriophage T4) |
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| Description: | P04527 |
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| Residue: | 187 |
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| Sequence: | MSLFKDDIQLNEHQVAWYSKDWTAVQSAADSFKEKAENEFFEIIGAINNKTKCSIAQKDY
SKFMVENALSQFPECMPAVYAMNLIGSGLSDEAHFNYLMAAVPRGKRYGKWAKLVEDSTE
VLIIKLLAKRYQVNTNDAINYKSILTKNGKLPLVLKELKGLVTDDFLKEVTKNVKEQKQL
KKLALEW
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| BDBM36318 |
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| BDBM50118233 |
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| Name | BDBM36318 |
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| Synonyms: | 5-carboxylate-indolyl- 2'-deoxyriboside triphosphate | 5-cyclohexyl-indolyl- 2'-deoxyriboside triphosphate | d5-CITP |
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| Type | Small organic molecule |
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| Emp. Form. | C14H18NO14P3 |
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| Mol. Mass. | 517.2123 |
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| SMILES | [H][C@]1(O)C[C@@]([H])(O[C@]1([H])COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc2cc(ccc12)C(O)=O |
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| Structure | 
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