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TargetCathepsin B
LigandBDBM36327
Substrate/CompetitorBDBM36388
Meas. Tech.Assay name: Protease Inhibition Assay
pH5.5±0
Temperature310.15±0 K
IC50 1.2e+2± 0 nM
Citation Kato DBoatright KMBerger ABNazif TBlum GRyan CChehade KASalvesen GSBogyo M Activity-based probes that target diverse cysteine protease families. Nat Chem Biol 1:33-8 (2005) [PubMed]  Article
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Cathepsin B
Name:Cathepsin B
Synonyms:n/a
Type:Protein
Mol. Mass.:37463.53
Organism:Rattus norvegicus
Description:P00787
Residue:339
Sequence:
MWWSLIPLSCLLALTSAHDKPSSHPLSDDMINYINKQNTTWQAGRNFYNVDISYLKKLCG
TVLGGPNLPERVGFSEDINLPESFDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMSDR
ICIHTNGRVNVEVSAEDLLTCCGIQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGCL
PYTIPPCEHHVNGSRPPCTGEGDTPKCNKMCEAGYSTSYKEDKHYGYTSYSVSDSEKEIM
AEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDVMGGHAIRILGWGIENGVPYWLVANSW
NVDWGDNGFFKILRGENHCGIESEIVAGIPRTQQYWGRF
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BDBM36327
BDBM36388
NameBDBM36327
Synonyms:Z-FG-AOMK 9a
TypeSmall organic molecule
Emp. Form.C29H30N2O6
Mol. Mass.502.5583
SMILESCc1cccc(C)c1C(=O)OCC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)OCc1ccccc1
Structure
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