Reaction Details |
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Target | Kinesin-like protein KIF11 [D130V] |
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Ligand | BDBM50220156 |
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Substrate/Competitor | n/a |
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Meas. Tech. | HCT116-D130V IC95 biaryl selected |
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pH | 6.8±0 |
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IC50 | 675±0.0 nM |
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Citation | Luo, L; Parrish, CA; Nevins, N; McNulty, DE; Chaudhari, AM; Carson, JD; Sudakin, V; Shaw, AN; Lehr, R; Zhao, H; Sweitzer, S; Lad, L; Wood, KW; Sakowicz, R; Annan, RS; Huang, PS; Jackson, JR; Dhanak, D; Copeland, RA; Auger, KR ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism. Nat Chem Biol3:722-6 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Kinesin-like protein KIF11 [D130V] |
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Name: | Kinesin-like protein KIF11 [D130V] |
Synonyms: | EG5 | KIF11 | KIF11_HUMAN | KNSL1 | KSP Mutant (D130V) | TRIP5 | kinesin spindle protein Mutant (D130V) |
Type: | PROTEIN |
Mol. Mass.: | 119124.02 |
Organism: | Homo sapiens (Human) |
Description: | Kinesin-like spindle protein HKSP |
Residue: | 1056 |
Sequence: | MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADK
SSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERS
PNEEYTWEEVPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSE
RLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFS
VTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVIT
ALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNIL
NKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIV
ELIEKIGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEY
ITSALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNS
LFNNMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHV
SQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLKHIFKT
SLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQ
ELCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFHSQKFCADSDGFS
QELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSLNER
EQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNE
TIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLM
MLNCSENNKEETIPDVDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHKKSHGK
DKENRGINTLERSKVEETTEHLVTKSRLPLRAQINL
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BDBM50220156 |
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n/a |
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Name | BDBM50220156 |
Synonyms: | (R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-3-fluoro-4-methylbenzamide | CHEMBL436624 | SB-731489 |
Type | Small organic molecule |
Emp. Form. | C30H32ClFN4O2 |
Mol. Mass. | 535.052 |
SMILES | CC(C)[C@@H](N(CCCN)C(=O)c1ccc(C)c(F)c1)c1nc2cc(Cl)ccc2c(=O)n1Cc1ccccc1 |
Structure |
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