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TargetAurora kinase A
LigandBDBM36467
Substrate/Competitorn/a
Meas. Tech.Aurora A Inhibition Assay
pH9.5±0
Temperature289.15±0 K
IC50 6.3e+3± 0 nM
Citation Clark MAAcharya RAArico-Muendel CCBelyanskaya SLBenjamin DRCarlson NRCentrella PAChiu CHCreaser SPCuozzo JWDavie CPDing YFranklin GJFranzen KDGefter MLHale SPHansen NJIsrael DIJiang JKavarana MJKelley MSKollmann CSLi FLind KMataruse SMedeiros PFMesser JAMyers PO'Keefe HOliff MCRise CESatz ALSkinner SRSvendsen JLTang Lvan Vloten KWagner RWYao GZhao BMorgan BA Design, synthesis and selection of DNA-encoded small-molecule libraries. Nat Chem Biol 5:647-54 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Aurora kinase A
Name:Aurora kinase A/Targeting protein for Xklp2
Synonyms:ARK1 | AURKA | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1
Type:Serine/threonine-protein kinase
Mol. Mass.:45830.98
Organism:Homo sapiens (Human)
Description:n/a
Residue:403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM36467
n/a
NameBDBM36467
Synonyms:2-(4-(2-Methoxyphenethylamino)-6-(methyl((S)-1-phenylethyl)amino)-1,3,5-triazin-2-ylamino)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanamide | DEL-A, 8
TypeSmall organic molecule
Emp. Form.C31H35N9O2
Mol. Mass.565.6687
SMILESCOc1ccccc1CCNc1nc(NC(Cc2c[nH]c3ncccc23)C(N)=O)nc(n1)N(C)[C@@H](C)c1ccccc1
Structure
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