| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase A |
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| Ligand | BDBM36470 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Aurora A Inhibition Assay |
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| pH | 9.5±0 |
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| Temperature | 289.15±0 K |
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| IC50 | 2.7e+2±n/a nM |
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| Citation |  Clark, MA; Acharya, RA; Arico-Muendel, CC; Belyanskaya, SL; Benjamin, DR; Carlson, NR; Centrella, PA; Chiu, CH; Creaser, SP; Cuozzo, JW; Davie, CP; Ding, Y; Franklin, GJ; Franzen, KD; Gefter, ML; Hale, SP; Hansen, NJ; Israel, DI; Jiang, J; Kavarana, MJ; Kelley, MS; Kollmann, CS; Li, F; Lind, K; Mataruse, S; Medeiros, PF; Messer, JA; Myers, P; O'Keefe, H; Oliff, MC; Rise, CE; Satz, AL; Skinner, SR; Svendsen, JL; Tang, L; van Vloten, K; Wagner, RW; Yao, G; Zhao, B; Morgan, BA Design, synthesis and selection of DNA-encoded small-molecule libraries. Nat Chem Biol5:647-54 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Aurora kinase A |
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| Name: | Aurora kinase A |
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| Synonyms: | AIK | AIRK1 | ARK-1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK15 GN | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | Serine/threonine-protein kinase aurora-A | Synonyms=AIK | aurora-2 | hARK1 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 45830.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O14965 |
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| Residue: | 403 |
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| Sequence: | MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
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| BDBM36470 |
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| n/a |
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| Name | BDBM36470 |
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| Synonyms: | 2-(4-(3,4-Dimethoxyphenylamino)-6-(quinolin-6-ylamino)-1,3,5-triazin-2-ylamino)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanamide | DEL-A, 11 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H28N10O3 |
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| Mol. Mass. | 576.6085 |
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| SMILES | COc1ccc(Nc2nc(NC(Cc3c[nH]c4ncccc34)C(N)=O)nc(Nc3ccc4ncccc4c3)n2)cc1OC |
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| Structure | 
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