Reaction Details |
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Target | Aurora kinase A |
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Ligand | BDBM36471 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Aurora A Inhibition Assay |
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pH | 9.5±0 |
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Temperature | 289.15±0 K |
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IC50 | 5.1e+3±n/a nM |
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Citation | Clark, MA; Acharya, RA; Arico-Muendel, CC; Belyanskaya, SL; Benjamin, DR; Carlson, NR; Centrella, PA; Chiu, CH; Creaser, SP; Cuozzo, JW; Davie, CP; Ding, Y; Franklin, GJ; Franzen, KD; Gefter, ML; Hale, SP; Hansen, NJ; Israel, DI; Jiang, J; Kavarana, MJ; Kelley, MS; Kollmann, CS; Li, F; Lind, K; Mataruse, S; Medeiros, PF; Messer, JA; Myers, P; O'Keefe, H; Oliff, MC; Rise, CE; Satz, AL; Skinner, SR; Svendsen, JL; Tang, L; van Vloten, K; Wagner, RW; Yao, G; Zhao, B; Morgan, BA Design, synthesis and selection of DNA-encoded small-molecule libraries. Nat Chem Biol5:647-54 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Aurora kinase A |
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Name: | Aurora kinase A |
Synonyms: | AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1 |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 45830.98 |
Organism: | Homo sapiens (Human) |
Description: | O14965 |
Residue: | 403 |
Sequence: | MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
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BDBM36471 |
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n/a |
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Name | BDBM36471 |
Synonyms: | DEL-A, 12 | N2-(2-Methoxyphenethyl)-N4-methyl-N6-(quinolin-6-yl)-1,3,5-triazine-2,4,6-triamine |
Type | Small organic molecule |
Emp. Form. | C22H23N7O |
Mol. Mass. | 401.4643 |
SMILES | CNc1nc(NCCc2ccccc2OC)nc(Nc2ccc3ncccc3c2)n1 |
Structure |
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