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Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
LigandBDBM36435
Substrate/CompetitorBDBM22111
Meas. Tech.Enzyme Activity Assay
pH7.5±0
Temperature298.15±0 K
Kd 0.046±0.0 nM
Citation Gutierrez, JALuo, MSingh, VLi, LBrown, RLNorris, GEEvans, GBFurneaux, RHTyler, PCPainter, GFLenz, DHSchramm, VL Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases. ACS Chem Biol2:725-34 (2007) [PubMed]  Article
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5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Name:5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Synonyms:5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | Methylthioadenosine Nucleosidase (MTAN)
Type:Enzyme
Mol. Mass.:24739.13
Organism:Neisseria meningitidis
Description:C6S634
Residue:233
Sequence:
MSLKTVTVIGAMEQEIELLREMMENVKAVSFGKFAAYEGELAGKRMVLALSGIGKVNAAV
ATAWLIHQFAPDCVINTGSAGGLGKGLKVGDVVVGTEIAHHDVDVTAFGYVWGQVPQLPA
RFASDGILIETAKRAARTFEGAAVEQGLIVSGDRFVHSSEGVAEIRKHFPEVKAVEMEAA
AIAQTCHQLETPFVIIRAVSDSADEKADISFDEFLKTAAANSAKMVAEIVKSL
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  Blast E-value cutoff:
BDBM36435
BDBM22111
NameBDBM36435
Synonyms:(3R,4S)-1-[(9-Deaza-adenin-9-yl)methyl]-4-ethylthio-methyl-3-hydroxypyrrolidine, 8 | CID11404039 | DADMe-ImmA-Et
TypeSmall organic molecule
Emp. Form.C14H21N5OS
Mol. Mass.307.414
SMILESCCSC[C@H]1CN(Cc2c[nH]c3c(N)ncnc23)C[C@@H]1O
Structure
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