| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosylhomocysteine nucleosidase |
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| Ligand | BDBM22113 |
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| Substrate/Competitor | BDBM22111 |
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| Meas. Tech. | Enzyme Activity Assay |
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| pH | 7.5±0 |
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| Temperature | 298.15±0 K |
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| Kd | 0.571±0.0 nM |
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| Citation |  Gutierrez, JA; Luo, M; Singh, V; Li, L; Brown, RL; Norris, GE; Evans, GB; Furneaux, RH; Tyler, PC; Painter, GF; Lenz, DH; Schramm, VL Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases. ACS Chem Biol2:725-34 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Adenosylhomocysteine nucleosidase |
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| Name: | Adenosylhomocysteine nucleosidase |
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| Synonyms: | 5'-methylthioadenosine nucleosidase | MTN | Methylthioadenosine Nucleosidase (MTAN) |
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| Type: | Enzyme |
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| Mol. Mass.: | 25233.34 |
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| Organism: | Helicobacter pylori |
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| Description: | D0IQW9 |
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| Residue: | 231 |
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| Sequence: | MVQKIGILGAMREEITPILELFGVDFEEIPLGGNVFHKGVYHDKEIIVAYSKIGKVHSTL
TTTSMILAFGVQKVLFSGVAGSLNKDLKINDLLVAIQLVQHDVDLSAFNHPLGFIPESAI
FIETSESLNALAKKVANEQHITLKEGVIASGDQFVHSKERKEFLISEFKASAVEMEGASV
AFVCQKFGVPCCVLRSISDNADEEANMSFDAFLEKSAQTSAKFLKSMVDKL
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| BDBM22113 |
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| BDBM22111 |
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| Name | BDBM22113 |
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| Synonyms: | (3R,4S)-1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl}methyl)-4-[(methylsulfanyl)methyl]pyrrolidin-3-ol | (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylsulfanyl)methyl]pyrrolidin-3-ol | (3R,4S)-1-[(9-Deazaadenin-9-yl)methyl]-3-hydroxy-4-methylthiomethylpyrrolidine, 7 | DADMe-ImmA-Me | MT-DADMe-ImmA |
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| Type | n/a |
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| Emp. Form. | C13H19N5OS |
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| Mol. Mass. | 293.388 |
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| SMILES | CSC[C@H]1CN(Cc2c[nH]c3c(N)ncnc23)C[C@@H]1O |r| |
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| Structure | 
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