Reaction Details |
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Target | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase |
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Ligand | BDBM50170093 |
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Substrate/Competitor | BDBM22111 |
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Meas. Tech. | Enzyme Activity Assay |
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pH | 7.5±0 |
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Temperature | 298.15±0 K |
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Kd | 77±0.0 nM |
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Citation | Gutierrez, JA; Luo, M; Singh, V; Li, L; Brown, RL; Norris, GE; Evans, GB; Furneaux, RH; Tyler, PC; Painter, GF; Lenz, DH; Schramm, VL Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases. ACS Chem Biol2:725-34 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase |
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Name: | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase |
Synonyms: | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | MTNN_STAAC | Methylthioadenosine Nucleosidase (MTAN) | mtnN |
Type: | Enzyme |
Mol. Mass.: | 24526.81 |
Organism: | Staphylococcus aureus |
Description: | Q5HFG2 |
Residue: | 228 |
Sequence: | MIGIIGAMEEEVTILKNKLTQLSEISVAHVKFYTGILKDREVVITQSGIGKVNAAISTTL
LINKFKPDVIINTGSAGALDESLNVGDVLISDDVKYHDADATAFGYEYGQIPQMPVAFQS
SKPLIEKVSQVVQQQQLTAKVGLIVSGDSFIGSVEQRQKIKKAFPNAMAVEMEATAIAQT
CYQFNVPFVVVRAVSDLANGEAEMSFEAFLEKAAVSSSQTVEALVSQL
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BDBM50170093 |
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BDBM22111 |
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Name | BDBM50170093 |
Synonyms: | 2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-3,4-dihydroxy-5-methylsulfanylmethyl-pyrrolidinium | ImmA-Me |
Type | Small organic molecule |
Emp. Form. | C12H18N5O2S |
Mol. Mass. | 296.368 |
SMILES | CSCC1[NH2+]C(C(O)C1O)c1c[nH]c2c(N)ncnc12 |
Structure |
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