| Reaction Details |
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 | Report a problem with these data |
| Target | Farnesyl pyrophosphate synthase |
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| Ligand | BDBM36509 |
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| Substrate/Competitor | BDBM36499 |
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| Meas. Tech. | Biophysical assay |
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| pH | 7.4±0 |
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| Temperature | 296.15±0 K |
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| IC50 | 6e+3±n/a nM |
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| Citation |  Jahnke, W; Rondeau, JM; Cotesta, S; Marzinzik, A; Pellé, X; Geiser, M; Strauss, A; Götte, M; Bitsch, F; Hemmig, R; Henry, C; Lehmann, S; Glickman, JF; Roddy, TP; Stout, SJ; Green, JR Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery. Nat Chem Biol6:660-6 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Farnesyl pyrophosphate synthase |
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| Name: | Farnesyl pyrophosphate synthase |
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| Synonyms: | Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324 |
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| Type: | Enzyme |
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| Mol. Mass.: | 48272.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14324 |
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| Residue: | 419 |
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| Sequence: | MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
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| BDBM36509 |
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| BDBM36499 |
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| Name | BDBM36509 |
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| Synonyms: | 3-(Carboxymethyl)-5,7-dichloro-1H-indole-2-carboxylic acid, 10 | CID46398845 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H7Cl2NO4 |
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| Mol. Mass. | 288.084 |
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| SMILES | OC(=O)Cc1c([nH]c2c(Cl)cc(Cl)cc12)C(O)=O |
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| Structure | 
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