Reaction Details |
| Report a problem with these data |
Target | Farnesyl pyrophosphate synthase |
---|
Ligand | BDBM36511 |
---|
Substrate/Competitor | BDBM36499 |
---|
Meas. Tech. | Biophysical assay |
---|
pH | 7.4±0 |
---|
Temperature | 296.15±0 K |
---|
IC50 | 8e+1±n/a nM |
---|
Citation | Jahnke, W; Rondeau, JM; Cotesta, S; Marzinzik, A; Pellé, X; Geiser, M; Strauss, A; Götte, M; Bitsch, F; Hemmig, R; Henry, C; Lehmann, S; Glickman, JF; Roddy, TP; Stout, SJ; Green, JR Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery. Nat Chem Biol6:660-6 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Farnesyl pyrophosphate synthase |
---|
Name: | Farnesyl pyrophosphate synthase |
Synonyms: | Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324 |
Type: | Enzyme |
Mol. Mass.: | 48272.89 |
Organism: | Homo sapiens (Human) |
Description: | P14324 |
Residue: | 419 |
Sequence: | MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
|
|
|
BDBM36511 |
---|
BDBM36499 |
---|
Name | BDBM36511 |
Synonyms: | 5-((2-Carboxy-1H-benzo[g]indol-1-yl)methyl)isoxazole-3-carboxylic acid, 12 | CID46398842 |
Type | Small organic molecule |
Emp. Form. | C18H12N2O5 |
Mol. Mass. | 336.2983 |
SMILES | OC(=O)c1cc(Cn2c(cc3ccc4ccccc4c23)C(O)=O)on1 |
Structure |
|