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TargetFarnesyl pyrophosphate synthase
LigandBDBM36511
Substrate/CompetitorBDBM36499
Meas. Tech.Biophysical assay
pH7.4±0
Temperature296.15±0 K
IC50 8e+1±n/a nM
Citation Jahnke, WRondeau, JMCotesta, SMarzinzik, APellé, XGeiser, MStrauss, AGötte, MBitsch, FHemmig, RHenry, CLehmann, SGlickman, JFRoddy, TPStout, SJGreen, JR Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery. Nat Chem Biol6:660-6 (2010) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Farnesyl pyrophosphate synthase
Name:Farnesyl pyrophosphate synthase
Synonyms:Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324
Type:Enzyme
Mol. Mass.:48272.89
Organism:Homo sapiens (Human)
Description:P14324
Residue:419
Sequence:
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
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  Blast E-value cutoff:
BDBM36511
BDBM36499
NameBDBM36511
Synonyms:5-((2-Carboxy-1H-benzo[g]indol-1-yl)methyl)isoxazole-3-carboxylic acid, 12 | CID46398842
TypeSmall organic molecule
Emp. Form.C18H12N2O5
Mol. Mass.336.2983
SMILESOC(=O)c1cc(Cn2c(cc3ccc4ccccc4c23)C(O)=O)on1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: