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TargetLysosomal acid glucosylceramidase
LigandBDBM36512
Substrate/CompetitorBDBM18352
Meas. Tech.Enzymatic Activity Assay
pH5.2±0
Temperature310.15±0 K
Ki 152± 26 nM
IC50 1.5e+2± 9 nM
Citation Witte, MDKallemeijn, WWAten, JLi, KYStrijland, ADonker-Koopman, WEvan den Nieuwendijk, AMBleijlevens, BKramer, GFlorea, BIHooibrink, BHollak, CEOttenhoff, RBoot, RGvan der Marel, GAOverkleeft, HSAerts, JM Ultrasensitive in situ visualization of active glucocerebrosidase molecules. Nat Chem Biol6:907-13 (2010) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Lysosomal acid glucosylceramidase
Name:Lysosomal acid glucosylceramidase
Synonyms:Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_HUMAN | GC | GCase | GLUC | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase)
Type:Enzyme
Mol. Mass.:59724.64
Organism:Homo sapiens (Human)
Description:The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source.
Residue:536
Sequence:
MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNAT
YCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGF
GGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDD
FQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQP
GDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIA
RDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAK
ATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDW
NLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQK
NDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
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BDBM36512
BDBM18352
NameBDBM36512
Synonyms:CID164227 | Cylcophellitol, 3 | US11826435, Compound 1.3
TypeSmall organic molecule
Emp. Form.C7H12O5
Mol. Mass.176.1672
SMILESOC[C@H]1[C@H]2O[C@H]2[C@H](O)[C@@H](O)[C@@H]1O
Structure
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