| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Heat shock protein HSP 90-beta |
|---|
| Ligand | BDBM31044 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | AlphaScreen Assay |
|---|
| Kd | 365±0.0 nM |
|---|
| Citation |  Yi, F; Regan, L A novel class of small molecule inhibitors of Hsp90. ACS Chem Biol3:645-54 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Heat shock protein HSP 90-beta |
|---|
| Name: | Heat shock protein HSP 90-beta |
|---|
| Synonyms: | HS90B_HUMAN | HSP 84 | HSP 90 | HSP90AB1 | HSP90B | HSPC2 | HSPCB | Heat Shock Protein 90 (Hsp90) | Heat shock protein HSP 90 (Hsp90) |
|---|
| Type: | Molecular Chaperone |
|---|
| Mol. Mass.: | 83229.45 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08238 |
|---|
| Residue: | 724 |
|---|
| Sequence: | MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT
DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG
ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE
DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE
YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA
EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ
KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG
LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA
NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE
TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM
EEVD
|
|
|
|---|
| BDBM31044 |
|---|
| n/a |
|---|
| Name | BDBM31044 |
|---|
| Synonyms: | 1-Ethyl-6-methyl-3-thiophen-2-yl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione | 1-ethyl-6-methyl-3-(2-thienyl)pyrimido[5,4-e][1,2,4]triazine-5,7-quinone | 1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1,2,4]triazine-5,7-dione | 1-ethyl-6-methyl-3-thiophen-2-ylpyrimido[5,4-e][1,2,4]triazine-5,7-dione | MLS000033110 | SMR000008918 | US9073941, 610 | cid_653297 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H11N5O2S |
|---|
| Mol. Mass. | 289.313 |
|---|
| SMILES | CCn1nc(nc2c1nc(=O)n(C)c2=O)-c1cccs1 |
|---|
| Structure | 
|
|---|
Search and Browse
