Reaction Details |
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Target | Protein O-GlcNAcase |
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Ligand | BDBM50182804 |
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Substrate/Competitor | BDBM18365 |
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Meas. Tech. | Enzyme Inhibition Assay |
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pH | 4.25±0 |
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Temperature | 303.15±0 K |
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Ki | 2.36e+4± 9.7e+2 nM |
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Citation | Ho, CW; Popat, SD; Liu, TW; Tsai, KC; Ho, MJ; Chen, WH; Yang, AS; Lin, CH Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors. ACS Chem Biol5:489-97 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Protein O-GlcNAcase |
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Name: | Protein O-GlcNAcase |
Synonyms: | 2-acetamido-2-deoxy-β-D-glucopyranosidase (O-GlcNAcase) | Beta-N-acetylhexosaminidase | Beta-hexosaminidase (O-GlcNAcase) | Bifunctional protein NCOAT | HEXC | KIAA0679 | MEA5 | MGEA5 | N-acetyl-beta-D-glucosaminidase (O-GlcNAcase) | O-glycoprotein 2-acetamido-2-deoxy-β-D-glucopyranosidase (O-GlcNAcase) | OGA | OGA_HUMAN | Protein O-GlcNAcase |
Type: | Enzyme |
Mol. Mass.: | 102874.67 |
Organism: | Homo sapiens (Human) |
Description: | O60502 |
Residue: | 916 |
Sequence: | MVQKESQATLEERESELSSNPAASAGASLEPPAAPAPGEDNPAGAGGAAVAGAAGGARRF
LCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLM
TLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNM
CAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPNVSQSPYLRTVGEK
LLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRS
TELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSEDSTVSIQIKLE
NEGSDEDIETDVLYSPQMALKLALTEWLQEFGVPHQYSSRQVAHSGAKASVVDGTPLVAA
PSLNATTVVTTVYQEPIMSQGAALSGEPTTLTKEEEKKQPDEEPMDMVVEKQEETDHKND
NQILSEIVEAKMAEELKPMDTDKESIAESKSPEMSMQEDCISDIAPMQTDEQTNKEQFVP
GPNEKPLYTAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKD
SEKIEEWRSRAAKFEEMCGLVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQW
LGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPY
FPKDEASVYKICREMYDDGVGLPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYA
LGTVDVTPFIKKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFP
SLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIA
KMEGFPKDVVILGRSL
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BDBM50182804 |
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BDBM18365 |
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Name | BDBM50182804 |
Synonyms: | 2-ACETAMIDO-1,2-DIDEOXYNOJIRMYCIN | CHEMBL382689 | Iminocyclitol, 5 | N-((3S,4R,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)piperidin-3-yl)acetamide | N-[4,5-dihydroxy-6-(hydroxymethyl)piperidin-3-yl]acetamide, 1 |
Type | Small organic molecule |
Emp. Form. | C8H16N2O4 |
Mol. Mass. | 204.2236 |
SMILES | CC(=O)N[C@H]1CN[C@H](CO)[C@@H](O)[C@@H]1O |
Structure |
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